Medicines for treatment of HIV/AIDS, Cancer, Hepatitis C , Breast Cancer, Blood Cancer
Raltegravir (MK-0518, brand name Isentress)
Etravirine (brand name Intelence, formerly known as TMC125)
Pegylated interferon alpha 2a and 2b
Trastuzumab injection (Herceptin)
What is Herceptin (Trastuzumab)?
Herceptin (Trastuzumab) is a treatment for women with breast cancer whose tumors have too much HER2 protein. This type of cancer is known as "HER2-positive", "HER2+", or "HER2 over expressing". HER2+ tumors tend to grow and spread more quickly than tumors that are not HER2+. This is why it is so important to find out your cancer's HER2 status.
Who is Herceptin for?
- Herceptin has 2 approved uses in metastatic breast cancer:
- Herceptin in combination with the chemotherapy drug Taxol® (paclitaxel) is approved for the first line treatment of Human Epidermal growth factor Receptor 2-positive (HER2+) metastatic breast cancer
- Herceptin alone is approved for the treatment of HER2+ breast cancer in patients who have received one or more chemotherapy courses for metastatic disease
What possible Serious Side Effects and Additional Important Safety Information should I know about Herceptin?
Heart Problems and Monitoring
- Herceptin treatment can result in heart problems, including those without symptoms (reduced heart function) and those with symptoms (congestive heart failure). The risk and seriousness of these heart problems were highest in people who received both Herceptin and a certain type of chemotherapy (anthracycline). One patient died in an adjuvant (early) breast cancer trial of significantly weakened heart muscle.
- Your doctor will evaluate your heart function before and during treatment. For adjuvant breast cancer therapy, your doctor will also evaluate heart function after the end of treatment. Your doctor will stop Herceptin therapy if you exhibit weakening of the heart muscle or changes in the heart muscle structure.
- If you are taking Herceptin and have stopped treatment temporarily because of significant heart problems, your doctor should monitor your heart health more frequently.
Infusion Reactions and Lung Problems
- Some patients have had serious infusion reactions and lung problems; infusions reactions leading to death have been reported.
- Symptoms usually happen during or within 24 hours of taking Herceptin.
- Your infusion should be temporarily stopped if you experience shortness of breath or very low blood pressure.
- Your doctor should monitor you until these symptoms completely go away.
- Your doctor may have you completely stop Herceptin treatment if you have:
- A severe allergic reaction
- Swelling
- Lung problems
- Swelling of the lungs
- Severe shortness of breath
Pregnancy
- Herceptin can cause harm to the fetus (unborn baby), in some cases death to the fetus, when taken by a pregnant woman.
Worsening of Low White Blood Cell Counts Due to Chemotherapy
- Worsening of low white blood cell counts to serious and life-threatening levels and associated fever were higher in patients taking Herceptin in combination with chemotherapy when compared with those who received chemotherapy alone.
HER2 Testing
- You must have a HER2 test to determine if your cancer is HER2-positive before taking Herceptin, as benefit has only been shown in patients whose tumors are HER2-positive
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